Blood Angiotensin II Levels of Normal and Hypertensive Subjects
Authors:
- K. J. CattKCK. J. Catt
- M. D. CainMCM. D. Cain
- P. Z. ZimmetPZP. Z. Zimmet
- E. CranECE. Cran
Abstract
A specific radioimmunoassay for angiotensin II has shown that its normal concentration in arterial blood is 2·4±1·2 (S.D.) mμg./l00 ml.; the venous level is consistently below this value, being usually 50–75% of it. Definite rises in blood angiotensin II levels were found in some patients with hypertension, both essential and secondary to renal disease. Extremely low levels were observed in two anephric women, and in one patient with Conn's syndrome. This radioimmunoassay offers a valuable alternative to renin bioassay in evaluation of the role of the renal pressor system in clinical disorders associated with hypertension and aldosteronism.Keywords
This publication has 10 references indexed in Scilit:
- Measurement of Plasma Angiotensin II and Correlation with Renin ActivityThe Journal of Clinical Endocrinology & Metabolism, 1968
- Metabolism and blood levels following infusion of a radioactive analog of angiotensinAmerican Journal of Physiology-Legacy Content, 1968
- Characterization and Source of a Renin-like Enzyme in Anephric Humans1The Journal of Clinical Endocrinology & Metabolism, 1968
- MEASUREMENT OF ANGIOTENSIN II IN BLOODThe Lancet, 1967
- RADIOIMMUNOASSAY FOR DETERMINING PLASMA-LEVELS OF ANGIOTENSIN II IN MANThe Lancet, 1967
- Radioimmunoassay of Angiotensin in Human PlasmaNature, 1967
- Angiotensin blood levels in hypertensive and non-hypertensive diseases.1966
- Suppression of Plasma Renin Activity in Primary AldosteronismJAMA, 1964
- THE ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN THE HYPERTENSION ASSOCIATED WITH RENAL VASCULAR DISEASE.1964
- NEW PROCEDURES FOR MEASUREMENT OF HUMAN PLASMA ANGIOTENSIN plus RENIN ACTIVITY LEVELS1964