Diphenylhydantoin Inhibition of Sodium Conductance in Squid Giant Axon
Authors:
- 1 July 1972
- journal article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (7) , 1758-1760
Abstract
Diphenylhydantoin, in concentration of 5-50 μM, decreases the early, transient (sodium) currents of voltage-clamped squid giant axons. These effects are dose-dependent and largely reversible. It appears that diphenylhydantoin reduces the number of open, early, transient (sodium) channels.Keywords
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