UHRF2 promotes DNA damage response by decreasing p21 via RING finger domain
Authors:
- 19 June 2018
- journal article
- research article
- Published by Springer Nature in Biotechnology Letters
- Vol. 40 (8) , 1181-1188
Abstract
To investigate the interaction of E3 ubiquitin ligase UHRF2 with p21 and the mechanism of UHRF2 in repairing DNA damage caused by hydroxyurea (HU) in HEK293 cells.Keywords
Funding Information
- National Natural Science Foundation of China (No. 81772178)
This publication has 15 references indexed in Scilit:
- Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damageDNA Repair, 2016
- Control of Trx1 redox state modulates protection against methyl methanesulfonate-induced DNA damage via stabilization of p21The Journal of Biochemistry, 2015
- A novel role for non-ubiquitinated FANCD2 in response to hydroxyurea-induced DNA damageOncogene, 2015
- Uhrf2 is important for DNA damage response in vascular smooth muscle cellsBiochemical and Biophysical Research Communications, 2013
- γH2AX as a marker of DNA double strand breaks and genomic instability in human population studiesMutation Research - Reviews in Mutation Research, 2013
- p21 promotes error-free replication-coupled DNA double-strand break repairNucleic Acids Research, 2012
- NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressorCell Cycle, 2011
- p21 in cancer: intricate networks and multiple activitiesNature Reviews Cancer, 2009
- Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosisOncogene, 2007
- UV Irradiation Triggers Ubiquitin-Dependent Degradation of p21WAF1 to Promote DNA RepairCell, 2003