Intramolecular Suzuki–Miyaura Reaction for the Total Synthesis of Signal Peptidase Inhibitors, Arylomycins A2 and B2
- 23 July 2010
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 16 (34) , 10523-10534
Abstract
Development of the total syntheses of arylomycins A1 and B2 is detailed. Key features of our approach include 1) formation of 14‐membered meta,meta‐cyclophane by an intramolecular Suzuki–Miyaura reaction; 2) incorporation of N‐Me‐4‐hydroxyphenylglycine into the cyclization precursor, which avoids the late‐stage low‐yielding N‐methylation step; 3) segment coupling of a fully elaborated peptide side chain to the macrocycle, which makes the synthesis highly convergent. Overall, arylomycin A2 was obtained in 13 steps from L‐Tyr for the longest linear sequence, in 13 % overall yield. Arylomycin B2 was synthesized in 10 steps from L‐3‐nitro‐Tyr, in 10 % overall yield.Keywords
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