Common variants in HNF-1 α and risk of type 2 diabetes
- 11 October 2006
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 49 (12) , 2882-2891
Abstract
Mutations in the hepatocyte nuclear factor 1-α gene (HNF-1α, now known as the transcription factor 1 gene [TCF1]) cause the most common monogenic form of diabetes, MODY3, but it is not known if common variants in HNF-1a are associated with decreased transcriptional activity or phenotypes related to type 2 diabetes, or whether they predict future type 2 diabetes.Keywords
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