Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex
Authors:
- Peter van Den ElsenPEPeter van Den Elsen
- Beth-Ann ShepleyBSBeth-Ann Shepley
- Jannie BorstJBJannie Borst
- John E. ColiganJCJohn E. Coligan
- Alexander F. MarkhamAMAlexander F. Markham
- Stuart OrkinSOStuart Orkin
- Cox TerhorstCTCox Terhorst
- 1 November 1984
- journal article
- Published by Springer Nature in Nature
- Vol. 312 (5993) , 413-418
Abstract
The complete amino acid sequence of one of the polypeptide chains of the human T3/T-cell receptor complex, the T3 glycoprotein (T3-delta-chain) of relative molecular mass 20,000, was deduced from cDNA clones derived from HPB-ALL cells and a human T-cell clone. Inspection of the 171-amino acid sequence reveals a signal peptide, a 79-amino acid extracellular domain, one transmembrane region and a 44-amino acid intracellular domain which show no sequence homology with members of the T-cell receptor/immunoglobulin/MHC multi-gene family. The T3 delta-chain is coded for by a single-copy gene the expression of which is restricted to T lymphocytes in humans and mice.Keywords
This publication has 40 references indexed in Scilit:
- The δ- and ε-chains of the human T3/T-cell receptor complex are distinct polypeptidesNature, 1984
- Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequencesNature, 1984
- T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4.Journal of Experimental Medicine, 1984
- Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.Journal of Experimental Medicine, 1983
- A simple method for displaying the hydropathic character of a proteinJournal of Molecular Biology, 1982
- Membrane Proteins. The Amino Acid Composition of Membrane-Penetrating SegmentsEuropean Journal of Biochemistry, 1981
- Distinctive functional characteristics of human „T”︁ lymphocytes defined by E rosetting or a monoclonal anti‐T cell antibodyEuropean Journal of Immunology, 1981
- Analysis of gene control signals by DNA fusion and cloning in Escherichia coliJournal of Molecular Biology, 1980
- 3′ Non-coding region sequences in eukaryotic messenger RNANature, 1976
- Detection of specific sequences among DNA fragments separated by gel electrophoresisJournal of Molecular Biology, 1975