Unveiling the Role of Pseudomonas aeruginosa Quorum Sensing Inhibitors: The Road So Far

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Abstract
ESKAPE bacteria represent a global threat to public health. These microorganisms employ a type of cell–cell communicationnamed “quorum sensing (QS) system,” which involves the activation of specific signals to modulate drug resistance and pathogenic behaviors. Noteworthy, resistance of Pseudomonas aeruginosa to antibiotics is increasing, thus leading to a greater interest in the development of new antibacterial compounds by exploring valuable targets such as its complex QS system. This review intends to provide an extensive report about the advances in the identification of promising P. aeruginosa QS inhibitors as potential novel therapeutic options. This work represents a comprehensive analysis of research articles available on Pubmed, Scopus, and Google Scholar, from January 2020 to July 2025, referring to promising antivirulence compounds, affecting P. aeruginosa QS system.

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