Investigations into the Production and Interconversion of Phomoidrides A−D
Authors:
- 24 April 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 3 (10) , 1443-1445
Abstract
Fermentation of ATCC 74256 led to the isolation and identification of C7 epimers of phomoidride A (CP-225,917) and phomoidride B (CP-263,114). We suggest the names phomoidrides C and D for these new fermentation products. Studies on the effect of pH on the distribution of phomoidrides A−D suggest phomoidride B (CP-263,114) is the first-formed secondary metabolite and the source of the remaining three phomoidrides.Keywords
This publication has 15 references indexed in Scilit:
- Total Synthesis of (−)-CP-263,114 (Phomoidride B)Journal of the American Chemical Society, 2000
- Studies Toward an Asymmetric Synthesis of CP-263,114 and CP-225,917Collection of Czechoslovak Chemical Communications, 2000
- Investigations into a Biomimetic Approach toward CP-225,917 and CP-263,114The Journal of Organic Chemistry, 1999
- Biosynthetic Studies on the Fungal Secondary Metabolites CP-225,917 and CP-263,114Journal of the American Chemical Society, 1999
- An approach to the synthesis of CP-263,114: complementary routes to the bicyclic ring system via two kinds of fragmentation reactionTetrahedron Letters, 1999
- A Stereospecific Geminal Alkylation Scheme En Route To CP-225, 917 and CP-263,114Angewandte Chemie International Edition, 1998
- Synthetic studies on CP-225,917 and CP-263,114Tetrahedron Letters, 1998
- Synthesis of the Bicyclo[4.4.1]decenone Core of CP-225,917 and CP-263,114Synlett, 1998
- CP-225,917 and CP-263,114: Novel Ras Farnesylation Inhibitors from an Unidentified Fungus. 2. Structure ElucidationJournal of the American Chemical Society, 1997
- CP-225,917 and CP-263,114, Novel Ras Farnesylation Inhibitors from an Unidentified Fungus. I. Taxonomy, Fermentation, Isolation, and Biochemical Properties.The Journal of Antibiotics, 1997