Transplantation of CD34 + Hematopoietic Progenitor Cells*
Authors:
- Roy B. JonesRJRoy B. Jones
- Scott I. BearmanSBScott I. Bearman
- Malcolm H. PurdyMPMalcolm H. Purdy
- Wilbur A. FranklinWFWilbur A. Franklin
- Shelly HeimfeldSHShelly Heimfeld
- Ronald J. BerensonRBRonald J. Berenson
- 1 January 1994
- journal article
- research article
- Published by SAGE Publications in Journal of Hematotherapy
- Vol. 3 (2) , 145-147
Abstract
Sixty-six stage IV breast cancer patients received high dose chemotherapy followed by autologous transplantation of CD34-positive (+) cells obtained from the bone marrow and/or granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood. Grafts were examined for the presence of tumor using conventional histology and immunocytochemical staining. Patients achieved a granulocyte count of 500 x 109/liter 10-12 days posttransplant, with a platelet count of >20 x 109/liter in 14-15 days. Enrichment of CD34+ cells from the peripheral blood progenitor cell (PBPC) collections resulted in a 1.3 to 4.0 log depletion of breast cancer cells from the graft.Keywords
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