Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG).
Authors:
- G J QuigleyGQG J Quigley
- A H WangAWA H Wang
- G UghettoGUG Ughetto
- G van der MarelGMG van der Marel
- J H van BoomJBJ H van Boom
- A RichARA Rich
- 1 December 1980
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (12) , 7204-7208
Abstract
The structure of the crystalline daunomycin-d(CpGpTpApCpG) complex has been solved by x-ray diffraction analysis. The DNA forms a six-base-pair right-handed double helix with two daunomycin molecules intercalated in the d(CpG) sequences. The daunomycin aglycone chromophore is oriented at right angles to the long dimension of the DNA base pairs and the cyclohexene ring rests in the minor groove. Substituents on this ring have hydrogen bonding interactions to the base pairs above and below the intercalation site. These appear to be specific for anthracycline antibiotics. The amino sugar lies in the minor groove of the double helix without bonding to the DNA. The DNA double helix is distorted in a novel manner in accommodating the drug.Keywords
This publication has 16 references indexed in Scilit:
- Crystal structure analysis of a complete turn of B-DNANature, 1980
- Molecular structure of a left-handed double helical DNA fragment at atomic resolutionNature, 1979
- 3 The Molecular Basis for the Action of Some DNA-Binding Drugs1979
- Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compoundNature, 1978
- DNA double helical fragment at atomic resolutionNature, 1978
- Visualization of drug-nucleic acid interactions at atomic resolutionJournal of Molecular Biology, 1977
- Visualization of drug-nucleic acid interactions at atomic resolutionJournal of Molecular Biology, 1977
- Visualization of drug-nucleic acid interactions at atomic resolutionJournal of Molecular Biology, 1977
- The degree of unwinding of the DNA helix by ethidiumJournal of Molecular Biology, 1974
- Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: Evidence for molecular models involving intercalationJournal of Molecular Biology, 1970