Hypertension Due to Blockade of Adenosine Receptors*

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Abstract
Chronic treatment of rats with 90 μg/kg/day DPSPX (1,3‐dipropyl‐8‐sulphophenylxanthine) during seven days leads to a hypertensive state which is characterized by marked morphological changes of the blood vessel walls as well as by important functional alterations. While the angiotensin‐converting enzyme (ACE) inhibitor captopril and the antagonist of angiotensin II AT 1 receptors losartan prevent the development of both hypertension and morphological changes, the selective β1‐adrenoceptor antagonist atenolol could prevent only the increase in blood pressure. It is concluded that at least two factors are involved in the development of the hypertensive state.

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