Plus Disease in Retinopathy of Prematurity

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Abstract
Retinopathy of prematurity (ROP) is a vasoproliferative disease affecting low-birth-weight infants. An International Classification for ROP (ICROP) has been developed to standardize clinical diagnosis.1 Multicenter randomized trials such as the Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) and Early Treatment for Retinopathy of Prematurity studies have found that severe ROP may be treated successfully by laser photocoagulation or cryotherapy.2,3 Pharmacological treatments are being studied.4 Despite these advances, ROP continues to be a leading cause of childhood blindness throughout the world.

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