The evolving role of telomerase inhibitors in the treatment of cancer
Author:
- 1 January 2003
- journal article
- review article
- Published by Informa Healthcare in Current Medical Research and Opinion
- Vol. 19 (6) , 470-472
Abstract
SUMMARYTelomerase is a ribonucleoprotein that maintains telomeres and is essential for cellular immortality and tumour growth. The differential expression of telomerase in cancer cells makes it an attractive therapeutic target. Anti-sense oligonucleotides directed against the RNA template of hTR and small molecules that can interact and stabilise the G-quadruplex represent promising therapeutic strategies. Human trials investigating the potential role of the catalytic subunit hTERT as a universal cancer vaccine have already commenced. Alternative lengthening of telomeres (ALT) and efficacy delay remain important limitations to anti-telomerase therapy.Keywords
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