Polyoxazoline Thermoresponsive Micelles as Radionuclide Delivery Systems

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Abstract
Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2‐methyl‐2‐oxazoline‐block‐(2‐isopropyl‐2‐oxazoline‐co‐2‐butyl‐2‐oxazoline)‐block‐2‐methyl‐2‐oxazoline]. These polymers are molecularly dissolved in aqueous millieu below the cloud point temperature (CPT) of the thermoresponsive central block and above CPT form polymer micelles at CMC 5–10 × 10−5 g · mL−1 with diameter ≈200 nm. The phenolic moiety introduced into the copolymer allowed radionuclide labeling with iodine‐125 ongoing in good yield with sufficient in vitro stability under model conditions. magnified image
Funding Information
  • Academy of Sciences of the Czech Republic (KAN 200200651)
  • Grant Agency of the Czech Republic (# P207/10/P054, # 202/09/2078)
  • Ministry of Education, Youth and Sports of the Czech Republic (# IM 4635608802)

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