Sculpting infant soothability: the role of prenatal SSRI antidepressant exposure and neonatal SLC6A4 methylation status
- 2 June 2016
- journal article
- research article
- Published by Wiley in Developmental Psychobiology
- Vol. 58 (6) , 745-758
Abstract
The role of prenatal Selective Serotonin Reuptake Inhibitor (SSRI) exposure and SLC6A4 promoter methylation status in shaping soothability at 3 and 6 months of age, for infants exposed to antidepressant medication prenatally (n = 46) and those not exposed (n = 69) was investigated. SSRI exposure status and duration of exposure (number of days) were examined along with neonatal methylation status at mean CpG 9,10 and via factor analysis across 10 CpG sites yielding PC1 (CpGs sites: 3,4,5,7) and PC2 (CpG 1,8). Analyses revealed interactions for methylation markers and SSRI exposure variables. A significant interaction between SSRI exposure and mean SLC6A4 methylation at CpG 9,10 and separately for PC1 emerged, controlling for multiple birth/medical and background covariates (e.g., Apgar scores, maternal education). Increased neonatal methylation status was associated with increased soothability changes from 3 to 6 months among infants prenatally exposed to SSRIs.Keywords
This publication has 80 references indexed in Scilit:
- Global Epigenomic Reconfiguration During Mammalian Brain DevelopmentScience, 2013
- Early Neurological Outcome of Young Infants Exposed to Selective Serotonin Reuptake Inhibitors during Pregnancy: Results from the Observational SMOK StudyPLOS ONE, 2013
- Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perceptionProceedings of the National Academy of Sciences, 2012
- Maternal depression and anxiety are associated with altered gene expression in the human placenta without modification by antidepressant use: Implications for fetal programmingDevelopmental Psychobiology, 2011
- Prenatal maternal stress programs infant stress regulationJournal of Child Psychology and Psychiatry, 2010
- Using the ASEBA to Screen for Callous Unemotional Traits in Early Childhood: Factor Structure, Temporal Stability, and UtilityJournal of Psychopathology and Behavioral Assessment, 2010
- Methylation at SLC6A4 is linked to family history of child abuse: An examination of the Iowa Adoptee sampleAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2010
- Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaquesGenes, Brain and Behavior, 2010
- Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of DepressionJAMA, 2009
- The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption StudiesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007