[Rituximab-induced interstitial pneumonitis: report of two cases and literature review].

Authors:
  • BPBao-Hong Ping
    Bao-Hong Ping
  • CYChun-Yan Yue
    Chun-Yan Yue
  • YGYa Gao
    Ya Gao
  • BWBin Wu
    Bin Wu
  • JHJia-Qiong Hong
    Jia-Qiong Hong
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  • 1 January 2015
    • journal article
    • case report
Abstract
We report two cases of rituximab (RTX)-induced interstitial pneumonia in two lymphoma patients receiving RTX treatment. Interstitial pneumonia was successfully managed in these two cases after a one-week-long intervention with corresponding treatments without affecting further treatment of the primary disease. RTX-induced interstitial pneumonia is characterized by a latent onset with an unclear pathological mechanism and absence of typical symptoms. High-resolution CT scan can provide valuable evidence for early diagnosis of RTX-induced interstitial pneumonia, which might be attributed partially to an increased susceptibility to P. jirovecii and fungal infection due to prolonged RTX treatment.