The Placenta Epigenome–Brain Axis: Placental Epigenomic and Transcriptomic Responses that Preprogram Cognitive Impairment
Authors:
- Anastasia N FreedmanAFAnastasia N Freedman
- Lauren A EavesLELauren A Eaves
- Julia E RagerJRJulia E Rager
- Lisa SmeesterLSLisa Smeester
- Jacqueline BangmaJBJacqueline Bangma
- Hudson P SantosHSHudson P Santos
- Robert M JosephRJRobert M Joseph
- Thomas Michael O’sHeaTOThomas Michael O’sHea
- Rebecca C FryRFRebecca C Fry
- 1 August 2022
- journal article
- research article
- Published by Taylor & Francis in Epigenomics
- Vol. 14 (15) , 897-911
Abstract
Aim: The placenta–brain axis reflects a developmental linkage where disrupted placental function is associated with impaired neurodevelopment later in life. Placental gene expression and the expres... Plain language summary Children born extremely preterm are at increased risk for neurodevelopmental impairments such as cerebral palsy, intellectual disability and autism. The biological processes ...Keywords
Funding Information
- National Institutes of Health (P42 ES005948, R01 ES019315)
- Office of the NIH Director (UH3OD023348)
- National Institute of Child Health and Human Development (UG3OD023348, R01HD092374, R03HD101413)
- National Institute of Neurologic Disorders and Stroke (U01NS040069, U01NS040069, U01NS040069)
- National Institute of Nursing Research (R01NR019245)
- National Institute for Occupational Safety and Health (T42/OH-008673)
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