Thymocytes are activated by toluene inhalation through the transcription factors NF‐κB, STAT5 and NF‐AT
- 26 October 2010
- journal article
- research article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 30 (7) , 656-660
Abstract
Toluene has been extensively examined for effects on the central nervous system. To investigate the influence of low-level inhalation of toluene on the naive immune cells, male C3H/HeN mice were exposed to filtered air (control) and 50 ppm of toluene for 3 weeks. Low-level exposure resulted in (1) increased proliferation of thymocytes, (2) IL-2 production induced in thymocytes and (3) activation of the transcription factors NF-κB, STAT5 and NF-AT in thymocytes. These results suggest that thymocytes are sensitive cells and T cell activators are candidates for biomarkers for low-level exposure to toluene on naive immune cells. Copyright © 2010 John Wiley & Sons, Ltd.Keywords
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