Paving the Path toward Porcine Organs for Transplantation
Author:
- 9 November 2017
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 377 (19) , 1891-1893
Abstract
The pig heart is a candidate organ for xenotransplantation, but endogenous retroviruses (ERVs) in the pig genome can infect human cells in vitro, raising the specter of zoonotic infection. A recent report describes the generation of healthy pigs free of replication-competent ERVs.Keywords
This publication has 5 references indexed in Scilit:
- Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9Science, 2017
- No PERV transmission during a clinical trial of pig islet cell transplantationVirus Research, 2017
- Genome-wide inactivation of porcine endogenous retroviruses (PERVs)Science, 2015
- Cytotoxic Effects during Knock Out of Multiple Porcine Endogenous Retrovirus (PERV) Sequences in the Pig Genome by Zinc Finger Nucleases (ZFN)PLOS ONE, 2015
- Microbiological safety of the first clinical pig islet xenotransplantation trial in New ZealandXenotransplantation, 2014