A Randomized Invasive Cardiac Electrophysiology Study of the Combined Ion Channel Blocker AZD1305 in Patients After Catheter Ablation of Atrial Flutter

Authors:
  • PRPekka Raatikainen
    Pekka Raatikainen
  • HWHåkan Walfridsson
    Håkan Walfridsson
  • AEAnders Englund
    Anders Englund
  • FHFinn Hegbom
    Finn Hegbom
  • OAOle-Gunnar Anfinsen
    Ole-Gunnar Anfinsen
  • KGKnut Gjesdal
    Knut Gjesdal
  • SPSteen Pehrson
    Steen Pehrson
  • SJSusanne Johansson
    Susanne Johansson
  • LFLars Frison
    Lars Frison
  • ABAnders R Berggren
    Anders R Berggren
  • NENils Edvardsson
    Nils Edvardsson
Publisher website
Google Scholar
Abstract
This study assessed the cardiac electrophysiological and hemodynamic effects of an intravenous infusion of the combined ion channel blocker AZD1305. After successful ablation of atrial flutter, patients were randomized to receive placebo (n = 12) or AZD1305 (n = 38) in 4 ascending dose groups. Electrophysiological and hemodynamic measurements were performed before and commencing 20 minutes after start of infusion. Left atrial effective refractory period increased dose and the primary outcome measure increased dose and plasma concentration dependently, with a mean increase of 55 milliseconds in dose group 3. There was a corresponding increase in right atrial effective refractory period of 84 milliseconds. The right ventricular effective refractory period and the paced QT interval also increased dose and concentration dependently, by 59 and 70 milliseconds, respectively, in dose group 3. There were indications of moderate increases of atrial, atrioventricular nodal, and ventricular conduction times. No consistent changes in intracardiac pressures were observed, but there was a small transient decrease in systolic blood pressure. Adverse events were consistent with the study population and procedure, and there were no signs of proarrhythmia despite marked delay in ventricular repolarization in some individuals. AZD1305 shows electrophysiological characteristics indicative of potential antiarrhythmic efficacy in atrial fibrillation.

This publication has 15 references indexed in Scilit: