Sex-dependent differences in bioenergetics of young mouse brain microvasculature: implications for oxygen-glucose deprivation and reoxygenation injury

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Abstract
Impact of sex on microvascular bioenergetics has never been studied. We measured oxygen consumption rates and extracellular acidification rates in mouse brain microvessels using Agilent Seahorse XFe24 analyzer. For the first time, we observed decreased mitochondrial respiratory and glycolytic function in brain microvessels of female mice compared with male mice. These sex-dependent differences in glycolysis and oxidative phosphorylation may increase the vulnerability/protection of the microvasculature to vascular cell injury.
Funding Information
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NS094834)
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NS114286)
  • HHS | NIH | National Institute on Aging (AG074489)
  • HHS | NIH | National Institute of General Medical Sciences (NS094834)
  • HHS | NIH | National Institute on Aging (AG047296)

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