STUDIES ON THE TRANSFERRINS OF ADULT SERUM, CORD SERUM, AND CEREBROSPINAL FLUID

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Nine of the twelve known variants of human transferrin have been resolved by the action of neuraminidase into stepwise patterns of four additional slower moving components whose relative intensities depended upon the concentration of enzyme. These components appeared to represent the stepwise removal of the four sialic acid residues from the transferrin molecule, and at large enzyme concentrations, almost all of the transferrin was reduced to the position of the slowest moving component. In contrast, the electrophoretic mobilities of haptoglobin, ceruloplasmin, and α2-macroglobulin showed a gradual decrease with increasing neuraminidase concentration.

This publication has 30 references indexed in Scilit: