Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Medical implants often fail as a result of so-called foreign body reactions during which inflammatory cells are recruited to implant surfaces. Despite the clinical importance of this phenomenon, the mechanisms involved in these reactions to biomedical implants in humans are not well understood. The results from animal studies suggest that both fibrinogen adsorption to the implant surface and histamine release by local mast cells are involved in biomaterial-mediated acute inflammatory responses. The purpose of this study was to test this hypothesis in humans.

This publication has 22 references indexed in Scilit: