Malignant lymphoma in congenital dyserythropoietic anaemia type III.
Authors:
- W G McCluggageWMW G McCluggage
- D HullDHD Hull
- E MayneEME Mayne
Open Access
- 1 July 1996
- journal article
- case report
- Published by BMJ in Journal of Clinical Pathology
- Vol. 49 (7) , 599-602
Abstract
A 60 year old woman with congenital dyserythropoietic anaemia (CDA) type III developed a malignant T cell lymphoma with cutaneous and widespread nodal involvement. Bone marrow aspirates showed erythroid hyperplasia and dyserythropoiesis with multinucleate erythroblasts and gigantoblasts, in keeping with CDA type III. Electron microscopy showed multinucleate erythroblasts with notably irregular nuclear outlines and intranuclear clefts. The development of malignant lymphoma in this patient, together with a documented high prevalence of monoclonal gammopathy and multiple myeloma and a single case of Hodgkin's disease, may indicate an increased incidence of lymphoproliferative disease in CDA type III.Keywords
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