Astrocytes as Drivers and Disruptors of Behavior: New Advances in Basic Mechanisms and Therapeutic Targeting

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Abstract
Astrocytes are emerging as key regulators of cognitive function and behavior. This review highlights some of the latest advances in the understanding of astrocyte roles in different behavioral domains across lifespan and in disease. We address specific molecular and circuit mechanisms by which astrocytes modulate behavior, discuss their functional diversity and versatility, and highlight emerging astrocyte-targeted treatment strategies that might alleviate behavioral and cognitive dysfunction in pathologic conditions. Converging evidence across different model systems and manipulations is revealing that astrocytes regulate behavioral processes in a precise and context-dependent manner. Improved understanding of these astrocytic functions may generate new therapeutic strategies for various conditions with cognitive and behavioral impairments.
Funding Information
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (R01 NS118569)
  • HHS | NIH | National Institute on Aging (R00 AG048222, F31 AG084165)
  • Alzheimer's Association Research Grant
  • Leon Levy Foundation Fellowship in Neuroscience
  • Centre National de la Recherche Scientifique (UPR3212)
  • Université de Strasbourg (UPR3212)
  • Agence Nationale de la Recherche (ANR) Jeune Chercheuse Jeune Chercheur (19-CE16-0011-0)
  • European Research Council
  • UNADEV-Aviesan
  • Fondation pour la Recherche Médicale
  • French Research Ministry
  • JSPS KAKENHI (JP21H00220, JP21H02588, JP23H04179)
  • JST FOREST (JPMJFR2249)
  • AMED (JP22dk0207063)
  • The German Research Foundation (SFB1089)

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