Design, synthesis and evaluation of fluorescent dihydropyridine–dihydropyrimidinone hybrids as inducers of cell-cycle arrest in a prostate cancer cell line via Aurora kinase interactions

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Abstract
Fluorescent DHP–DHPM hybrids demonstrated potent and selective antitumor activity against PC3 prostate cancer cells. Studies revealed selective inhibition of Aurora kinase C, G 0 /G 1 cell cycle arrest and modulate MAPK, AKT, and mTOR signaling pathways.
Funding Information
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2013/07607-8 -RAP)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2017/06146-8 -CBB)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2019/13104-5 -RAP)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2023/02032-9 -RJSO)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (2020/306747 -RAP)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (310438/2020-9 -DR)
  • Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (19/2551-0001767-7 -DR)

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