Amyloid Production in Human Myeloma Stem-Cell Culture, with Morphologic Evidence of Amyloid Secretion by Associated Macrophages

Authors:
  • BDBrian G. M. Durie
    Brian G. M. Durie
  • BPBruce Persky
    Bruce Persky
  • BSBarbara J. Soehnlen
    Barbara J. Soehnlen
  • TGThomas M. Grogan
    Thomas M. Grogan
  • SSSydney E. Salmon
    Sydney E. Salmon
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Abstract
IT is generally agreed that amyloid fibrils in patients with myeloma and acquired systemic amyloidosis are derived from monoclonal immunoglobulin light chains (Bence Jones proteins).1 , 2 The exact mechanisms responsible for extracellular deposition of the light-chain components as amyloid are less clear.2 , 3 It has been proposed that partial degradation of Bence Jones proteins occurs in the lysosomes of tissue macrophages, which then secrete amyloid into the extracellular environment, where polymerization occurs.4 , 5 Although considerable evidence supports this concept,6 7 8 9 10 11 12 there has been no direct confirmation.In this article we present the findings from human myeloma stem-cell culture with bone-marrow cells from a patient . . .

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