Photoactivation of Electron Donor–Acceptor Complexes for C(sp2)–H Amination of Arenes Using an Organocatalytic Acceptor
- 29 August 2025
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 27 (36) , 10011-10015
Abstract
This Letter describes the photocatalytic C(sp2)-H amination of electron-rich arenes with azoles via an electron donor-acceptor (EDA) pathway. The acceptor in this system is proposed to be a pyridin-1-ium salt generated in situ from the combination of pyridine and either LiOTf or HOTf. The reactions proceed with irradiation using 370 nm LEDs, and the pyridine/acid acceptor can serve as a catalyst under aerobic conditions. This represents a rare example of a catalytic acceptor in EDA photochemistry.Keywords
Funding Information
- Horace H. Rackham School of Graduate Studies, University of Michigan
- Arnold and Mabel Beckman Foundation
- National Institute of General Medical Sciences (R35GM1361332)
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