Pd/Chiral Phosphoric Acid-Enabled Asymmetric Intramolecular Double C–H Activation Reaction for the Synthesis of P-Stereogenic Benzophosphole Oxides
Authors:
- 3 February 2025
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 27 (6) , 1481-1486
Abstract
A Pd-catalyzed intramolecular asymmetric double C-H activation reaction was reported, and a BINOL skeleton-based chiral phosphoric acid (CPA) was identified as a suitable ligand for this transformation. A broad range of P-stereogenic benzophosphole oxides were synthesized in moderate to excellent yield with high levels of enantioselectivity (≤96% ee).Keywords
Funding Information
- Yangzhou University
- Inner Mongolia University
- National Natural Science Foundation of China (21871168, 22371150)
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