Copper‐Catalyzed Hydrodifluoroallylation of Terminal Alkynes to Access (E)‐1,1‐Difluoro‐1,4‐Dienes
Authors:
- 14 May 2020
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 362 (14) , 2852-2856
Abstract
A copper‐catalyzed regio‐ and stereoselective hydrodifluoroallylation of terminal alkynes was disclosed. This reaction employs easily available 3‐bromo‐3,3‐difluoropropene (BDFP) as the difluoroallylating reagent and 1,1,3,3‐tetramethyldisiloxane (TMDSO) as the hydride source, affording a variety of (E)‐1,1‐difluoro‐1,4‐dienes in moderate to good yields. The synthetic utility of this protocol has been demonstrated through the transformation of resulting (E)‐1,1‐difluoro‐1,4‐diene to difluoromethylated and trifluoromethylated derivatives. magnified imageKeywords
Funding Information
- National Natural Science Foundation of China (21421002, 21991211)
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