The Synthesis of Spirobitetraline Phosphoramidite Ligands and their Application in Rhodium‐Catalyzed Asymmetric Hydrogenation
Authors:
- 5 November 2007
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 349 (16) , 2477-2484
Abstract
A racemic 1,1′‐spirobitetralin‐8,8′‐diol (SBITOL) was conveniently synthesized from 3‐methoxybenzaldehyde in 26 % yield over 9 steps and resolved via its bis‐(S)‐camphorsulfonates. The corresponding chiral spirobitetraline monophosphoramidite ligands have been prepared and their rhodium complexes were applied in the asymmetric hydrogenation of dehydroamino esters with good to excellent enantioselectivities (up to 99.3 % ee).Keywords
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