Brain Neurotransmitters in Dystonia Musculorum Deformans
Authors:
- Oleh HornykiewiczOHOleh Hornykiewicz
- Stephen J. KishSKStephen J. Kish
- Lawrence E. BeckerLBLawrence E. Becker
- Irene FarleyIFIrene Farley
- Kathleen ShannakKSKathleen Shannak
- 7 August 1986
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 315 (6) , 347-353
Abstract
We examined histologically and biochemically the brains of two patients with generalized childhoodonset dystonia musculorum deformans. We found no important histologic changes in the basal ganglia, cerebral cortex, higher brain-stem nuclei, locus ceruleus, or raphe nuclei. Similarly, the activity of choline acetyltransferase and the levels of gamma-aminobutyric acid and glutamic acid in the cerebral cortex and basal ganglia were within the control range.Keywords
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