RNA-modifying enzymes and their function in a chromatin context
Authors:
- 3 October 2019
- journal article
- research article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 26 (10) , 858-862
Abstract
Exciting research has connected specific RNA modifications to chromatin, providing evidence for co-transcriptional deposition and function in gene regulation. Here we review insights gained from studying the co-transcriptional roles of RNA modifications, and their influence in normal and disease contexts. We also discuss how the availability of novel technical approaches could raise the translational potential of targeting RNA-modifying enzymes for the treatment of disease.Keywords
This publication has 109 references indexed in Scilit:
- NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAsCell Reports, 2013
- Identification of direct targets and modified bases of RNA cytosine methyltransferasesNature Biotechnology, 2013
- ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemiaProceedings of the National Academy of Sciences, 2012
- Human RNA Methyltransferase BCDIN3D Regulates MicroRNA ProcessingCell, 2012
- Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop CodonsCell, 2012
- Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemiaNature Medicine, 2012
- Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemiaNature Chemical Biology, 2012
- Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemiaNature, 2011
- RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemiaNature, 2011
- 5-methylcytosine in RNA: detection, enzymatic formation and biological functionsNucleic Acids Research, 2009