Asymmetric Synthesis of the Four Possible Fagomine Isomers
- 2 April 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (9) , 3603-3607
Abstract
The asymmetric synthesis of fagomine and its congeners 1−4 has been achieved by catalytic ring-closing metathesis (RCM). The synthesis involved the construction of the piperidene-type chiral building block 5 followed by dihydroxylation, starting from the d-serine-derived Garner aldehyde 6.Keywords
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