Catalytic Acceptorless Dehydrogenation (CAD) of Secondary Benzylic Alcohols into Value-Added Ketones Using Pd(II)–NHC Complexes
Authors:
- Abeer Nasser Al-RomaizanAbeer Nasser Al-Romaizan
- Manoj Kumar GangwarManoj Kumar Gangwar
- Ankit VermaAnkit Verma
- Salem M. BawakedSalem M. Bawaked
- Tamer S. SalehTamer S. Saleh
- Rahmah H. Al-AmmariRahmah H. Al-Ammari
- Ray J. ButcherRay J. Butcher
- Ibadur Rahman SiddiquiIbadur Rahman Siddiqui
- Mohamed Mokhtar M. MostafaMohamed Mokhtar M. Mostafa
Open Access
Abstract
For the creation of adaptable carbonyl compounds in organic synthesis, the oxidation of alcohols is a crucial step. As a sustainable alternative to the harmful traditional oxidation processes, transition-metal catalysts have recently attracted a lot of interest in acceptorless dehydrogenation reactions of alcohols. Here, using well-defined, air-stable palladium(II)–NHC catalysts (A–F), we demonstrate an effective method for the catalytic acceptorless dehydrogenation (CAD) reaction of secondary benzylic alcohols to produce the corresponding ketones and molecular hydrogen (H2). Catalytic acceptorless dehydrogenation (CAD) has been successfully used to convert a variety of alcohols, including electron-rich/electron-poor aromatic secondary alcohols, heteroaromatic secondary alcohols, and aliphatic cyclic alcohols, into their corresponding value-added ketones while only releasing molecular hydrogen as a byproduct.Keywords
Funding Information
- Deputyship for Research & Innovation (IFPRC-026-247-2020)
- Ministry of Education in Saudi Arabia (IFPRC-026-247-2020)
- Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah (IFPRC-026-247-2020)
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