Study on the Extrusion Molding Process of Polylactic Acid Micro Tubes for Biodegradable Vascular Stents

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Abstract
Polylactic acid (PLA) has been widely used in the field of medical devices. However, few studies have been conducted on the extrusion molding of PLA micro tubes for the preparation of biodegradable vascular stents. In this paper, the extrusion die for PLA single-cavity micro tubes was designed and manufactured by micro-extrusion theory. Taking the outer diameter, wall thickness, wall thickness uniformity and ovality of micro tubes as the evaluation index, the influence of the main extrusion process parameters on the evaluation index was studied. The experimental results show that the outer diameter and wall thickness are significantly affected by screw speed, pulling speed and gas flow rate; extrusion process parameters have little influence on wall thickness uniformity and ovality within a certain range, which mainly depends on the processing accuracy and assembly accuracy of the extrusion die. However, excessively high screw speed and low gas flow rate have significant effects on ovality. Finally, according to the influence of extrusion process parameters on the evaluation index, a series of micro tubes that meet the design requirements are extruded and carved into vascular stent structures.
Funding Information
  • Natural Science Foundation of Liaoning Province (2021-BS-261, LJKZ0604, LJKQZ2021140, LJKZ0605, Nos.11502044, U1906233, No.DUT17RC(3)104, 2019YFA0708804)
  • Basic scientific research projects of higher education institutions of Liaoning Provincial Department of Education (2021-BS-261, LJKZ0604, LJKQZ2021140, LJKZ0605, Nos.11502044, U1906233, No.DUT17RC(3)104, 2019YFA0708804)
  • National Natural Science Foundation of China (2021-BS-261, LJKZ0604, LJKQZ2021140, LJKZ0605, Nos.11502044, U1906233, No.DUT17RC(3)104, 2019YFA0708804)
  • Fundamental Research Funds for the Central Universities (2021-BS-261, LJKZ0604, LJKQZ2021140, LJKZ0605, Nos.11502044, U1906233, No.DUT17RC(3)104, 2019YFA0708804)
  • National Key R&D Program of China (2021-BS-261, LJKZ0604, LJKQZ2021140, LJKZ0605, Nos.11502044, U1906233, No.DUT17RC(3)104, 2019YFA0708804)

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