Advanced Antimicrobial and Anti-Infective Strategies to Manage Peri-Implant Infection: A Narrative Review

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Abstract
Despite reductions in bacterial infection and enhanced success rate, the widespread use of systemic antibiotic prophylaxis in implant dentistry is controversial. This use has contributed to the growing problem of antimicrobial resistance, along with creating significant health and economic burdens. The basic mechanisms that cause implant infection can be targeted by new prevention and treatment methods which can also lead to the reduction of systemic antibiotic exposure and its associated adverse effects. This review aims to summarize advanced biomaterial strategies applied to implant components based on anti-pathogenic mechanisms and immune balance mechanisms. It emphasizes that modifying the dental implant surface and regulating the early immune response are promising strategies, which may further prevent or slow the development of peri-implant infection, and subsequent failure.
Funding Information
  • Alpha Omega Foundation Canada Research Grant (165957)
  • International College of Prosthodontists (ICP) Research Grant (165957)
  • Canadian Institutes of Health Research (CHIR) PJT (165957)
  • Canada Foundation for Innovation, John R. Evans Leaders Fund (CFI_JELF)/Ontario Research Fund (ORF) (165957)

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