Telomerase Activity In Preleukemia And Acute Myelogenous Leukemia

Authors:
  • JYJie Yang
    Jie Yang
  • CAColleen Andrews
    Colleen Andrews
  • YCYi-Xin Chen
    Yi-Xin Chen
  • PTPaul Toofanfard
    Paul Toofanfard
  • RHRay-Win Huang
    Ray-Win Huang
  • EHErzsebet Horvath
    Erzsebet Horvath
  • HCHarpreet Chopra
    Harpreet Chopra
  • ARAzra Raza
    Azra Raza
  • HPHarvey D. Preisler
    Harvey D. Preisler
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Abstract
The development of acute leukemia from preleukemia involves the appearance of clones with increasing proliferative potential. The studies described here demonstrate that telomerase activity progressively increases as the bone marrow cells acquire increasing proliferative potential. This was demonstrated by measuring telomerase activity in normal bone marrow, in post-treatment lymphoma marrows with skewed Lyonization, and in MDS and AML marrows. The greater telomerase activity in myelodysplastic marrow than in normal marrow is not due to a higher proportion of blast cells or to a higher proliferative rate of the MDS marrow. These data demonstrate that the increasing proliferative potential of the marrow which occurs during the development of AML is associated with a simultaneous increase in telomerase activity.

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