Attenuated pressor and sympathetic neural responses to exercise in long-term breast cancer survivors: role of the muscle metaboreflex

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Abstract
Long-term breast cancer (BC) survivors previously treated with doxorubicin- and trastuzumab-based chemotherapy show reduced muscle metaboreflex activation, which partly explains attenuated pressor and sympathetic neural responses to exercise in this population. Importantly, these findings shed light on the blunted exercise-induced blood pressure increase observed in long-term BC survivors.
Funding Information
  • Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/211.526/2021)
  • Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/204.249/2025 (313975))
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico ((CNPq)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (# 304697/2020-6))
  • National Institutes of Health (R00HL159241)
  • Instituto D'Or de Pesquisa e Ensino

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