Truncation of the otoferlin transmembrane domain alters the development of hair cells and reduces membrane docking
Open Access
- 1 July 2021
- journal article
- research article
- Published by American Society for Cell Biology (ASCB) in Molecular Biology of the Cell
- Vol. 32 (14) , 1293-1305
Abstract
Release of neurotransmitter from sensory hair cells is regulated by otoferlin. Despite the importance of otoferlin in the auditory and vestibular pathways, the functional contributions of the domai...Keywords
This publication has 41 references indexed in Scilit:
- The C2 Domains of Otoferlin, Dysferlin, and Myoferlin Alter the Packing of Lipid BilayersBiochemistry, 2013
- Otoferlin Couples to Clathrin-Mediated Endocytosis in Mature Cochlear Inner Hair CellsJournal of Neuroscience, 2013
- TILLING - a shortcut in functional genomicsJournal of Applied Genetics, 2011
- Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusionJournal of Cell Biology, 2010
- Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cellsNature Neuroscience, 2010
- Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory mapNature Neuroscience, 2010
- Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cellHuman Molecular Genetics, 2009
- Direct Interaction of Otoferlin with Syntaxin 1A, SNAP-25, and the L-type Voltage-gated Calcium Channel CaV1.3Journal of Biological Chemistry, 2009
- Hearing Loss Alters the Subcellular Distribution of Presynaptic GAD and Postsynaptic GABAA Receptors in the Auditory CortexCerebral Cortex, 2008
- A new mathematical model for relative quantification in real-time RT-PCRNucleic Acids Research, 2001