Spatial patterns of cartilage loss in the medial femoral condyle in osteoarthritic knees: Data from the osteoarthritis initiative

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  • FIfor the OAI Investigators
    for the OAI Investigators
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Abstract
The objective of this study was to develop a technique for analyzing spatial patterns of cartilage loss in the medial femoral condyle (MF), and to study MF cartilage loss in participants of the Osteoarthritis Initiative. Using a 0.7mm sagittal double echo at steady state (DESS) sequence, 160 osteoarthritic knees from 80 participants with varying degrees of medial joint space narrowing were imaged at baseline and 1‐year follow‐up. MF cartilage was segmented and cartilage loss determined. Rate of change varied significantly (P = 0.0067) along the anterior‐posterior extension of the MF, with the greatest changes (−45 μm, −2.7%) observed 30‐60° posterior to the trochlear notch. The rate was greater in the central MF after excluding peripheral aspects of the MF from analysis. Sensitivity to change was greatest at 45‐75° (standardized response mean = −0.32) but was minimally affected by medial‐lateral trimming. In conclusion, the greatest sensitivity to change was achieved when analyzing the posterior aspect of the central, weight‐bearing MF. Magn Reson Med, 2010.

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