p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function
Authors:
- Shicheng LiuSLShicheng Liu
- Hitoshi YamauchiHYHitoshi Yamauchi
- 1 December 2009
- journal article
- Published by Elsevier in Cancer Letters
- Vol. 286 (2) , 240-249
Abstract
No abstract availableKeywords
This publication has 31 references indexed in Scilit:
- Molecular response to phototoxic stress of UVB-irradiated ketoprofen through arresting cell cycle in G2/M phase and inducing apoptosisBiochemical and Biophysical Research Communications, 2007
- p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cellsMolecular Cancer Therapeutics, 2007
- HIV Protease Inhibitor Nelfinavir Inhibits Growth of Human Melanoma Cells by Induction of Cell Cycle ArrestCancer Research, 2007
- Tumor Necrosis Factor-α Blocks Apoptosis in Melanoma Cells when BRAF Signaling Is InhibitedCancer Research, 2007
- A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen SpeciesCancer Research, 2006
- Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell linesBiochemical and Biophysical Research Communications, 2006
- Spontaneous and UV Radiation–Induced Multiple Metastatic Melanomas in Cdk4R24C/R24C/TPras MiceCancer Research, 2006
- Significance of skp2 expression in primary breast cancer.Clinical Cancer Research, 2006
- Cyclin A- and Cyclin E-Cdk Complexes Shuttle between the Nucleus and the CytoplasmMolecular Biology of the Cell, 2002
- p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27Current Biology, 1999