Redesigning Nature's Poisons to Create Anti-Tumor Reagents
Authors:
- 20 November 1987
- journal article
- clinical trial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 238 (4830) , 1098-1104
Abstract
Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.Keywords
This publication has 55 references indexed in Scilit:
- Emergence of immunoglobulin variants following treatment of a B cell leukemia with an immunotoxin composed of antiidiotypic antibody and saporin.Journal of Experimental Medicine, 1987
- Expression of ricin A chain in Escherichia coliFEBS Letters, 1987
- Evaluation of ricin A-chain immunotoxins directed against human T cellsCellular Immunology, 1986
- Replacing the complementarity-determining regions in a human antibody with those from a mouseNature, 1986
- Ribosome‐inactivating proteins up to dateFEBS Letters, 1986
- Modification of the carbohydrate in ricin with metaperiodate — cyanoborohydride mixturesEuropean Journal of Biochemistry, 1985
- Ricin B chain converts a non‐cytotoxic antibody‐ricin A chain conjugate into a potent and specific cytotoxic agentFEBS Letters, 1983
- Immunotoxins: A New Approach to Cancer TherapyScience, 1983
- Effects of Ricin on the Ribosomal Sites Involved in the Interaction of the Elongation FactorsEuropean Journal of Biochemistry, 1975
- THE HISTOLOGICAL CHANGES PRODUCED BY RICIN AND ABRIN INTOXICATIONSJournal of Experimental Medicine, 1897