Abstract
The endothelium has a regulatory role in several mechanisms, including vascular tone and coagulation. Abnormalities of the endothelium have been found to predict cardiovascular disease, sometimes independent of the classic cardiovascular risk factors such as raised von Willebrand factor (vWF) concentrations.3 Several studies have reported an association between low birth weight and different aspects of endothelial function.4,5 The objective of this study was to determine whether soluble markers of endothelial function and inflammation are associated with low birth weight in middle aged subjects.