Abstract
Transcription of the locus of enterocyte effacement (LEE) genes in enterohemorrhagicEscherichia coli(EHEC) is regulated by the LEE-encoded Ler and GrlR/GrlA proteins as well as the non-LEE-encoded regulator QseA. This work demonstrates that GrlR/GrlA activateLEE2transcription in a Ler-independent fashion, whereas transcription ofgrlRAis activated by QseA in both Ler-dependent and -independent manners.

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