Severe Neurologic Complication After Delayed Hemolytic Transfusion Reaction in 2 Children With Sickle Cell Anemia
Authors:
- Narcisse ElengaNarcisse Elenga
- Valérie MialouVMValérie Mialou
- Kamila KebaïliKKKamila Kebaïli
- Claire GalambrunCGClaire Galambrun
- Yves BertrandYBYves Bertrand
- Corinne PondarreCPCorinne Pondarre
- 1 December 2008
- journal article
- case report
- Published by Wolters Kluwer Health in Journal of Pediatric Hematology/Oncology
- Vol. 30 (12) , 928-930
Abstract
Although delayed hemolytic transfusion reaction (DHTR) has been widely recognized as a serious complication of red blood cell transfusion in patients with sickle cell disease (SCD), there is no consensus on its optimal management. Discontinuation of transfusion is recommended, whereas corticosteroids and immunoglobulins are considered to be beneficial. We report 2 children with sickle cell anemia who were diagnosed with DHTR and experienced a subsequent neurologic event in the course of treatment with corticosteroids. The role of corticosteroids as possible precipitating factors of neurologic complications is discussed. Pending a better understanding of the chain of events of DHTR, SCD children with DHTR should receive steroids with great caution.Keywords
This publication has 15 references indexed in Scilit:
- Steroid treatment in children with sickle-cell diseaseHaematologica, 2007
- Autoimmune Liver Disease in Three Children with Sickle Cell DiseaseJournal of Pediatric Gastroenterology and Nutrition, 2006
- Use of Intravenous Immunoglobulin and Intravenous Methylprednisolone in Hyperhaemolysis Syndrome in Sickle Cell DiseaseHematology, 2004
- Delayed Hemolytic Transfusion Reaction/Hyperhemolysis Syndrome in Children With Sickle Cell DiseasePediatrics, 2003
- Hyperhemolytic transfusion reaction in sickle cell diseaseTransfusion, 2001
- Beneficial Effect of Intravenous Dexamethasone in Children With Mild to Moderately Severe Acute Chest Syndrome Complicating Sickle Cell DiseaseBlood, 1998
- Granulocytosis causing sickle-cell crisisThe Lancet, 1998
- The sickle cell hemolytic transfusion reaction syndromeTransfusion, 1997
- High-Dose Intravenous Methylprednisolone Therapy for Pain in Children and Adolescents with Sickle Cell DiseaseNew England Journal of Medicine, 1994
- Stroke in a cohort of patients with homozygous sickle cell diseaseThe Journal of Pediatrics, 1992