Obesity, body weight regulation and the brain: insights from fMRI
Authors:
- 16 February 2018
- journal article
- review article
- Published by Oxford University Press (OUP) in British Journal of Radiology
- Vol. 91 (1089) , 20170910
Abstract
Obesity constitutes a major global health threat. Despite the success of bariatric surgery in delivering sustainable weight loss and improvement in obesity-related morbidity, effective non-surgical treatments are urgently needed, necessitating an increased understanding of body weight regulation. Neuroimaging studies undertaken in people with healthy weight, overweight, obesity and following bariatric surgery have contributed to identifying the neurophysiological changes seen in obesity and help increase our understanding of the mechanisms driving the favourable eating behaviour changes and sustained weight loss engendered by bariatric surgery. These studies have revealed a key interplay between peripheral metabolic signals, homeostatic and hedonic brain regions and genetics. Findings from brain functional magnetic resonance imaging (fMRI) studies have consistently associated obesity with an increased motivational drive to eat, increased reward responses to food cues and impaired food-related self-control...Keywords
This publication has 99 references indexed in Scilit:
- Body mass index correlates negatively with white matter integrity in the fornix and corpus callosum: A diffusion tensor imaging studyHuman Brain Mapping, 2011
- Metabolic and hedonic drives in the neural control of appetite: who is the boss?Current Opinion in Neurobiology, 2011
- The Gut Hormones PYY3-36 and GLP-17-36 amide Reduce Food Intake and Modulate Brain Activity in Appetite Centers in HumansCell Metabolism, 2011
- Long-Term Persistence of Hormonal Adaptations to Weight LossNew England Journal of Medicine, 2011
- Selective Reduction in Neural Responses to High Calorie Foods Following Gastric Bypass SurgeryAnnals of Surgery, 2011
- Life course variations in the associations between FTO and MC4R gene variants and body sizeHuman Molecular Genetics, 2009
- Brain structure and obesityHuman Brain Mapping, 2009
- Relation of reward from food intake and anticipated food intake to obesity: A functional magnetic resonance imaging study.Journal of Abnormal Psychology, 2008
- Aspects of Eating Behaviors “Disinhibition” and “Restraint” Are Related to Weight Gain and BMI in WomenObesity, 2008
- A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult ObesityScience, 2007