Serum Protein Binding of the Aminoglycoside Antibiotics
Authors:
- 1 September 1972
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 2 (3) , 214-216
Abstract
The binding of four aminoglycoside antibiotics by human serum was investigated under controlled conditions of physiological p H and temperature, by means of an ultrafiltration technique. No serum binding was demonstrable for gentamicin, tobramycin, or kanamycin, whereas streptomycin was 35% bound. Previous conflicting studies are discussed, and some of the pharmacological implications are considered.Keywords
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