The contribution of feedback loops between miRNAs, cytokines and growth factors to the pathogenesis of psoriasis
- 10 April 2018
- journal article
- review article
- Published by Wiley in Experimental Dermatology
- Vol. 27 (6) , 603-610
Abstract
The present review describes in detail the existent data regarding feedback loops between miRNAs and cytokines or growth factors in the psoriatic inflammation. We have chosen to describe the roles of miR‐31, miR‐21, miR‐146a, miR‐155, miR‐197 and miR‐99a in this process. This choice derives from the fact that among around 250 miRNAs being altered in the psoriatic lesion, the comprehensive functional role was described only in those detailed above. In addition, considering the molecular targets and the pathways, which may possibly be regulated by those miRNAs, it seems that they may be chosen as preferred targets for the therapy of psoriasis.Keywords
Funding Information
- Israel Cancer Association (20160038)
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