Docosahexaenoic acid-induced apoptosis is mediated by activation of mitogen-activated protein kinases in human cancer cells
Authors:
- Soyeon JeongSJSoyeon Jeong
- Kaipeng JingKJKaipeng Jing
- Nayeong KimNKNayeong Kim
- Soyeon ShinSSSoyeon Shin
- Soyeon KimSKSoyeon Kim
- Kyoung-Sub SongKSKyoung-Sub Song
- Jun-Young HeoJHJun-Young Heo
- Ji-Hoon ParkJPJi-Hoon Park
- Kang-Sik SeoKSKang-Sik Seo
- Jeongsu HanJHJeongsu Han
- Tong WuTWTong Wu
- Gi-Ryang KweonGKGi-Ryang Kweon
Open Access
- 3 July 2014
- journal article
- Published by Springer Nature in BMC Cancer
- Vol. 14 (1) , 481
Abstract
The role of omega-3 polyunsaturated fatty acids (ω3-PUFAs) in cancer prevention has been demonstrated; however, the exact molecular mechanisms underlying the anticancer activity of ω3-PUFAs are not fully understood. Here, we investigated the relationship between the anticancer action of a specific ω3-PUFA docosahexaenoic acid (DHA), and the conventional mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK), c-JUN N-terminal kinase (JNK) and p38 whose dysregulation has been implicated in human cancers.Keywords
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